Phenylpropanoid Glycosides from Orobanche caerulescens

Abstract

Two new phenylpropanoid glycosides, caerulescenoside (1), and 3′-methyl crenatoside (2), as well as five known phenylpropanoid glycosides [acteoside (3), isoacteoside (4), campneoside II (5), crenatoside (6), and desrhamnosyl acteoside (7)] were isolated from the whole plant of Orobanche caerulescens. The antioxidative effects of compounds 1 - 7 on human low-density lipoprotein were evaluated. All these compounds suppress concentration-dependently conjugated diene formation with IC₅₀ values of 1.25 ± 0.06, 2.97 ± 0.31, 0.31 ± 0.01, 1.01 ± 0.05, 1.15 ± 0.04, 1.69 ± 0.15, and 0.64 ± 0.03 μM, respectively. Comparison of their antioxidative activities with that of resveratrol (IC₅₀ : 6.75 ± 1.05 μM), a natural phenolic antioxidant isolated from grape, demonstrated that the prolonged effect on lag-time and the damping effect on oxidative rate by compounds 1 - 7 were all more potent.

Key words

Orobanchaceae - Orobanche caerulescens - phenylpropanoid glycosides - caerulescenoside - 3′-methyl crenatoside - antioxidant

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